Volume 1 ; Issue 1 ; in Month : Jan-June (2024) Article No : 105
Ayyappan S, Vigneshwaran G, Paul JK, et. al.

Abstract

Background: Pre-eclampsia is a complex condition that affects multiple systems in the body. It is characterized by the sudden development of high blood pressure and the presence of protein in the urine, or the sudden development of high blood pressure together with severe malfunction in organs, with or without protein in the urine. Pre-eclampsia usually occurs after 20 weeks of pregnancy or after childbirth. The classic clinical symptoms include hypertension, proteinuria, abnormal weight increases, and oedema. Unsecured iron ions in storage or transport proteins pose a risk as they can trigger free radical reactions. The presence of oxidative stress in preeclampsia can lead to an increase in transferrin saturation and a decrease in unsaturated iron binding capacity. This, in turn, can further exacerbate oxidative stress by reducing the serum's ability to buffer against redox-active iron through antioxidants. Methodology: The study was carried out at the department of Obstetrics and Gynecology and Biochemistry in Nandha Medical College and Hospital. The study will involve women who have been diagnosed with preeclampsia as cases, and normotensive healthy pregnant women as controls. Informed consent will be obtained from all participants. The systolic and diastolic blood pressure of all individuals will be observed. The spectrophotometer on the fully automated analyser AU680 (Beckman Coulter) will be used to measure the levels of serum iron and TIBC. Result: The average (mean) value of Iron for patients is 126.39, with a standard deviation (SD) of 39.53. In contrast, for controls, the average value is 83.86, with an SD of 25.48. The average value of TIBC for patients is 354.59, with a standard deviation of 52.58. For Controls, the Mean value is 417.0 and the Standard Deviation (SD) is 59.16. The P valve for both Iron and TIBC is less than 0.001. Conclusion: This study establishes that pregnant women with pre-eclampsia experience a notable increase in serum iron levels. Excessive iron could be considered a potential cause of oxidative stress, which may play a role in the development of preeclampsia.

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