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<title>Frontiers-in-Multidisciplinary-Research-and-Studies-ISSUE VOLUME Volume 3 ISSUE Issue 2</title>
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Frontiers-in-Multidisciplinary-Research-and-Studies: VOLUME Volume 3 ISSUE Issue 2, July-Dec 2026
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<title>Frontiers-in-Multidisciplinary-Research-and-Studies-ISSUE VOLUME Volume 3 ISSUE Issue 2</title>
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		<title>Proarrhythmogenic-Risk-of-Diazepam-in-the-Context-of-Electrolyte-Imbalance-A-Review-</title>
		<pubDate>13-Aug-2026</pubDate>
<link>http://fmrs.edwiserinternational.com/admin/uploads/6bmqCB.pdf</link>
		<author>Kumari-N-Fazal-B-Kumar-P-et-al-</author>
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		<category>Pharmaceutical Science,Medical Science,Clinical Science</category>
		<description>{<![CDATA[Potassium is the predominant intracellular cation, with its extracellular concentrations maintained. Among the different potassium disorders, hypokalaemia is a common clinical condition that increases the risk of life-threatening ventricular arrhythmias. Both triggers and substrates are required for the induction and maintenance of ventricular arrhythmias. Human ether-go-go related gene (HERG) potassium (K+) channels play a critical role in cardiac action potential repolarization. A large number of structurally diverse compounds bind to HERG and carry an unacceptably high risk of causing arrhythmias. On the other hand, drugs that increase HERG current may, at least in principle, prove useful for the treatment of long QT syndrome. A few blockers have been shown to increase HERG current at potentials close to the threshold for channel activation  a process referred to as facilitation. We evaluated the electrophysiological parameters before and after the intravenous infusion of diazepam cardiac patients to investigate the drug's antiarrhythmic effect. Diazepam did not significantly change the arterial pressure. After the intravenous infusion of diazepam, the sinus cycle length significantly shortened. No significant change in the maximal sinus node recovery time was noted. The atrial and ventricular effective refractory periods remain unchanged after the administration of diazepam. The effects of diazepam on potassium contractures, contraction threshold, and resting tension have been examined in rat soleus muscle fibres. Two actions of the drug were defined that could not be attributed to changes in the resting membrane potential or depolarisation in high potassium solutions. The major effect was an increase in the amplitude of submaximal tension during either twitches or potassium contractures and an increase in resting tension. Severe hyperkalaemia is a life-threatening electrolyte imbalance that may lead to fatal arrhythmias. ECG (electrocardiogram) and serum potassium levels are vital for diagnosing and stratifying the risk.]]>}</description>
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